Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection

PK Drain, KL Bajema, D Dowdy, K Dheda… - Clinical microbiology …, 2018 - Am Soc Microbiol
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Immunological consequences of strain variation within the Mycobacterium tuberculosis complex

LD Tientcheu, A Koch, M Ndengane… - European journal of …, 2017 - Wiley Online Library
In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally,
making it one of the leading causes of death due to an infectious disease. TB is caused by …

Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis

TS Rodrigues, BJ Conti, TFC Fraga-Silva… - Journal of Leucocyte …, 2020 - academic.oup.com
The innate response plays a crucial role in the protection against tuberculosis development.
Moreover, the initial steps that drive the host-pathogen interaction following Mycobacterium …

Mycobacterium tuberculosis clinical isolates of the Beijing and East-African Indian lineage induce fundamentally different host responses in mice compared to H37Rv

BC Mourik, JEM de Steenwinkel, GJ de Knegt… - Scientific reports, 2019 - nature.com
Substantial differences exist in virulence among Mycobacterium tuberculosis strains in
preclinical TB models. In this study we show how virulence affects host responses in mice …

Valproic acid promotes a decrease in mycobacterial survival by enhancing nitric oxide production in macrophages stimulated with IFN-γ

E Nieto-Patlán, J Serafín-López, I Wong-Baeza… - Tuberculosis, 2019 - Elsevier
Tuberculosis is one of the leading causes of mortality worldwide, it is caused by
Mycobacterium tuberculosis (Mtb), a bacteria that employs several strategies to evade the …

Stealing Survival: Iron Acquisition Strategies of Mycobacterium tuberculosis

G Shankar, Y Akhter - Biochimie, 2024 - Elsevier
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), faces iron
scarcity within the host due to immune defenses. This review explores the importance of iron …

Differential activation of innate and adaptive lymphocytes during latent or active infection with Mycobacterium tuberculosis

BP Ruiz‐Sánchez… - Microbiology and …, 2022 - Wiley Online Library
Most individuals infected with Mycobacterium tuberculosis (Mtb) have latent tuberculosis
(TB), which can be diagnosed with tests (such as the QuantiFERON‐TB Gold test [QFT]) that …

Regulation of the immune response by Mycobacterium tuberculosis Beijing genotype

M Campillo-Navarro, I Wong-Baeza… - … . London, UK: InTech, 2015 - books.google.com
Tuberculosis (TB) is an old infectious disease that has affected humans for millennia [1]. This
disease is caused by infection with bacilli belonging to the Mycobacterium tuberculosis (Mtb) …

Integrated bioinformatics analysis of dendritic cells hub genes reveal potential early tuberculosis diagnostic markers

X Wu, K Liu, S Li, W Ren, W Wang, Y Shang… - BMC Medical …, 2023 - Springer
Abstract Background Dendritic cells (DCs) are most potent antigen-processing cells and
play key roles in host defense against Mycobacterium tuberculosis (MTB) infection. In this …

Accelerating the preclinical development of effective vaccines for protection against Mycobacterium tuberculosis

HE Painter - 2021 - researchonline.lshtm.ac.uk
The Bacille Calmette–Guerin (BCG) vaccine offers partial protection against tuberculosis
(TB). Vaccines able to sufficiently contribute to global TB control are required urgently. The …