Beta-thalassemia is caused by the reduced (beta+) or absent (beta 0) synthesis of the beta
globin chains of the hemoglobin tetramer. Three clinical and hematological conditions of …

The biconcave shape and corresponding deformability of the human red blood cell (RBC) is
an essential feature of its biological function. This feature of RBCs can be critically affected …

CD8+ T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …

Sexual and asexual reproduction are found throughout the plant and animal kingdoms.
Asexual reproduction has its advantages, chief among which is that it does not require the …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

Mathematical models, which are based on a firm understanding of biological interactions,
can provide nonintuitive insights into the dynamics of host responses to infectious agents …

Plant biologists have long recognized that host defence against parasites and pathogens
can be divided into two conceptually different components: the ability to limit parasite burden …

A man dies because his body has rejected a heart transplant; a woman is crippled by
rheumatoid arthritis; a child goes into a coma that is brought on by cerebral malaria; another …