Background Sedentary lifestyle is a major risk factor for noncommunicable diseases such as
cardiovascular diseases, cancer and diabetes. It has been estimated that approximately 3.2 …

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Background Melatonin is widely available either on prescription for the treatment of sleep
disorders or as an over-the-counter dietary supplement. Melatonin has also recently been …

Melatonin is a hormone secreted by the pineal gland in accordance with the circadian
rhythm when the light level decreases. Reduction of melatonin secretion with age may be …

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Background The etiologies of chronic neurological diseases, which heavily contribute to
global disease burden, remain far from elucidated. Despite available umbrella reviews on …

Last year melatonin was 60 years old, or at least its discovery was 60 years ago. The
molecule itself may well be almost as old as life itself. So it is time to take yet another …

The chronic performance of implantable neural electrodes is hindered by inflammatory brain
tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin …

Septic cardiomyopathy (SCM) is a common complication of sepsis contributing to high
mortality rates. Its pathophysiology involves complex factors, including inflammatory …

Sunlight has participated in the development of all life forms on Earth. The micro-world and
the daily rhythms of plants and animals are strongly regulated by the light–dark rhythm …