Proton therapy is increasingly being used as a radiation therapy modality. There is
uncertainty about the biological effectiveness of protons relative to photon therapies as it …

Immunotherapy and targeted therapy are now commonly used in clinical trials in
combination with radiotherapy for several cancers. While results are promising and …

Simple Summary Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
death worldwide with slow progress in the development of effective therapies. The …

We have developed a time-dependent computational framework, hematological dose
(HEDOS), to estimate dose to circulating blood cells from radiation therapy treatment fields …

We have developed a novel 4D dynamic liver blood flow model, capable of accurate dose
estimation to circulating blood cells during liver-directed external beam radiotherapy …

Purpose Lymphopenia is a common adverse effect of radiation therapy (RT). Little is known
about the difference in lymphopenia between intensity modulated (photon) radiation therapy …

Pancreatic ductal adenocarcinoma (PDAC) represents a challenge in oncology, with limited
treatment options for advanced-stage patients. Chimeric antigen receptor T cell (CAR T) …

Immunotherapeutic agents have revolutionized cancer treatment over the past decade.
However, most patients fail to respond to immunotherapy alone. A growing body of …

Purpose Lymphopenia is now generally recognized as a negative prognostic factor in
radiotherapy. Already at the beginning of the century we demonstrated that high-energy …

PURPOSE To stratify patients and aid clinical decision making, we developed machine
learning models to predict treatment failure and radiation-induced toxicities after …