Direct photocatalyzed hydrogen atom transfer (d-HAT) can be considered a method of
choice for the elaboration of aliphatic C–H bonds. In this manifold, a photocatalyst (PCHAT) …

We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

Utilizing catalytic CuCl2 we report the functionalization of numerous feedstock chemicals via
the coupling of unactivated C (sp3)–H bonds with electron-deficient olefins. The active …

Oils are hydrophobic, but their degradation is frequently found to be accelerated in the
presence of water microdroplets. The direct chemical consequences of water–oil contact …

The intermediacy of alkoxy radicals in cerium-catalyzed C–H functionalization via H-atom
abstraction has been unambiguously confirmed. Catalytically relevant Ce (IV)–alkoxide …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

The selective functionalization of alkanes has long been recognized as a prominent
challenge and an arduous task in organic synthesis. Hydrogen atom transfer (HAT) …

Here we report the development of a C (sp3)–H cross-coupling platform enabled by the
catalytic generation of chlorine radicals by nickel and photoredox catalysis. Aryl chlorides …

The coupling of carboxylic acids and amines to form amide linkages is the most commonly
performed reaction in the pharmaceutical industry. Herein, we report a new strategy that …

The synergistic control of the SH2 transition states of hydrogen abstraction by polar and
steric effects provides a promising strategy in achieving site-selective C (sp3)–H …