Cancer associated human papillomaviruses

ME McLaughlin-Drubin, J Meyers, K Munger - Current opinion in virology, 2012 - Elsevier
A small group of human papillomaviruses (HPVs) cause almost all cervical carcinoma and a
significant percentage of other anogenital tract and oral carcinoma. Another group of HPVs …

Signaling pathways in HPV‐associated cancers and therapeutic implications

J Chen - Reviews in medical virology, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) are small double‐stranded circular DNA viruses with 8 kb
genomes. So far, more than 150 HPVs have been identified, and 12 types of HPVs have …

HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation

W Yin, N Egawa, K Zheng, H Griffin, P Tian… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPV) cause persistent infections by modulating epithelial
homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition …

Manipulation of epithelial differentiation by HPV oncoproteins

EA White - Viruses, 2019 - mdpi.com
Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial
differentiation is essential for the progression of papillomavirus replication, but differentiation …

TP63 functions as a tumor suppressor regulated by GAS5/miR-221-3p signaling axis in human non-small cell lung cancer cells

Q Shen, H Wang, L Zhang - Cancer Management and Research, 2023 - Taylor & Francis
Background Tumor protein p63 (TP63) has been proven to play a role as a tumor
suppressor in some human cancers, including non-small cell lung cancer (NSCLC). This …

P63 and P73 Activation in Cancers with p53 Mutation

BH Cai, YC Hsu, FY Yeh, YR Lin, RY Lu, SJ Yu… - Biomedicines, 2022 - mdpi.com
The members of the p53 family comprise p53, p63, and p73, and full-length isoforms of the
p53 family have a tumor suppressor function. However, p53, but not p63 or p73, has a high …

Effects of the antifungal agent ciclopirox in HPV‐positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis

JA Braun, AL Herrmann, JI Blase… - … journal of cancer, 2020 - Wiley Online Library
The malignant growth of human papillomavirus (HPV)‐positive cancer cells is dependent on
the continuous expression of the viral E6/E7 oncogenes. Here, we examined the effects of …

Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9

HY Cho, SW Lee, YH Jeon, DH Lee, GW Kim… - International journal of …, 2020 - mdpi.com
Overexpression of histone deacetylase 6 (HDAC6) and bromodomain-containing protein 4
(BRD4) is related to aggressiveness of head and neck squamous carcinoma (HNSCC) …

Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis

J Skelin, V Tomaić - Viruses, 2023 - mdpi.com
Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect
epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical …

CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 and has a therapeutic effect on HPV-induced neoplasia

M Ajiro, H Sakai, H Onogi, M Yamamoto, E Sumi… - Clinical Cancer …, 2018 - AACR
Purpose: Cervical cancer is one of the leading causes of cancer-related deaths among
women worldwide. The purpose of this study is to assess the therapeutic effect of the newly …