Materials for oral delivery of proteins and peptides

TD Brown, KA Whitehead, S Mitragotri - Nature Reviews Materials, 2020 - nature.com
Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

MK Shim, S Yang, IC Sun, K Kim - Advanced Drug Delivery Reviews, 2022 - Elsevier
As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …

Functional supramolecular systems: Design and applications

IS Antipin, MV Alfimov, VV Arslanov… - Russian Chemical …, 2021 - iopscience.iop.org
The interest in functional supramolecular systems for the design of innovative materials and
technologies, able to fundamentally change the world, is growing at a high pace. The huge …

[HTML][HTML] Thiolated polymeric hydrogels for biomedical application: Cross-linking mechanisms

S Summonte, GF Racaniello, A Lopedota… - Journal of Controlled …, 2021 - Elsevier
This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated
hyaluronic acid, chitosan, cyclodextrin, poly (ethylene glycol) and dextran that are cross …

Oral films: current status and future perspectives: I—galenical development and quality attributes

AF Borges, C Silva, JFJ Coelho, S Simões - Journal of Controlled Release, 2015 - Elsevier
Polymers are the most common excipients used in pharmaceutical dosage forms, and often
new applications and innovative polymers appear aiming to overcome unmet needs in the …

Crossing biological barriers with nanogels to improve drug delivery performance

JC Cuggino, ERO Blanco, LM Gugliotta… - Journal of Controlled …, 2019 - Elsevier
The current limitations in the use of nanocarriers to treat constantly evolving diseases call for
the design of novel and smarter drug delivery systems (DDS). Nanogels (NGs) are three …

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

C Leichner, M Jelkmann… - Advanced Drug Delivery …, 2019 - Elsevier
Thiolated polymers designated “thiomers” are obtained by covalent attachment of thiol
functionalities on the polymeric backbone of polymers. In 1998 these polymers were first …

Progress and current trends in the synthesis of novel polymers with enhanced mucoadhesive properties

RP Brannigan, VV Khutoryanskiy - Macromolecular Bioscience, 2019 - Wiley Online Library
Mucoadhesion is defined as the adherence of a synthetic or natural polymer to a mucosal
membrane via physical or chemical interactions. Mucoadhesive materials are widely used to …

Thiolation of biopolymers for developing drug delivery systems with enhanced mechanical and mucoadhesive properties: A review

V Puri, A Sharma, P Kumar, I Singh - Polymers, 2020 - mdpi.com
Biopolymers are extensively used for developing drug delivery systems as they are easily
available, economical, readily modified, nontoxic, biodegradable and biocompatible …

Thiol-and disulfide-based stimulus-responsive soft materials and self-assembling systems

DM Beaupre, RG Weiss - Molecules, 2021 - mdpi.com
Properties and applications of synthetic thiol-and disulfide-based materials, principally
polymers, are reviewed. Emphasis is placed on soft and self-assembling materials in which …