There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Major depressive disorder (MDD) is a prominent cause of disability worldwide. Current
antidepressant drugs produce full remission in only about one-third of MDD patients and …

The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with
its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of …

Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …

Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a
series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its …

The human body is populated by myriads of microorganisms throughout its surface and in
the cavities connected to the outside. The microbial colonisers of the intestine (microbiota) …