Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
MicroRNAs in NF-κB signaling
X Ma, LE Becker Buscaglia… - Journal of molecular cell …, 2011 - academic.oup.com
Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …
critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor …
Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents
Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist
conventional chemotherapy and are the major cause of relapse,. Hypomethylating agents …
conventional chemotherapy and are the major cause of relapse,. Hypomethylating agents …
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
In breast cancer, the increased stiffness of the extracellular matrix is a key driver of
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer
JU Marquardt, L Gomez-Quiroz, LOA Camacho… - Journal of …, 2015 - Elsevier
Background & Aims The cancer stem cells (CSCs) have important therapeutic implications
for multi-resistant cancers including hepatocellular carcinoma (HCC). Among the key …
for multi-resistant cancers including hepatocellular carcinoma (HCC). Among the key …
MicroRNAs as molecular switches in macrophage activation
The efficacy of macrophage-mediated inflammatory response relies on the coordinated
expression of key factors, which expression is finely regulated at both transcriptional and …
expression of key factors, which expression is finely regulated at both transcriptional and …
A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia
Cancers that appear pathologically similar often respond differently to the same drug
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …
regimens. Methods to better match patients to drugs are in high demand. We demonstrate a …
Targeting the NFκB signaling pathways for breast cancer prevention and therapy
The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …
commonly observed phenomenon in breast cancer. It facilitates the development of a …
MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts
JA Wallace, RM O'Connell - … Journal of the American Society of …, 2017 - ashpublications.org
Acute myeloid leukemia (AML) is a deadly hematologic malignancy characterized by the
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …
uncontrolled growth of immature myeloid cells. Over the past several decades, we have …
RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell …
X Zhang, X Zhao, W Fiskus, J Lin, T Lwin, R Rao… - Cancer cell, 2012 - cell.com
We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3,
and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate …
and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate …