Corneal dystrophies

YQ Soh, V Kocaba, JS Weiss, UV Jurkunas… - Nature Reviews …, 2020 - nature.com
Corneal dystrophies are broadly defined as inherited disorders that affect any layer of the
cornea and are usually progressive, bilateral conditions that do not have systemic effects …

[HTML][HTML] Molecular mechanisms of amyloid disaggregation

KJY Low, A Venkatraman, JS Mehta… - Journal of Advanced …, 2022 - Elsevier
Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …

Targeting of scavenger receptors stabilin-1 and stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression

CP Manta, T Leibing, M Friedrich, H Nolte, M Adrian… - Circulation, 2022 - Am Heart Assoc
Background: Scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are preferentially
expressed by liver sinusoidal endothelial cells. They mediate the clearance of circulating …

Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

M Li, H Huang, L Li, C He, L Zhu, H Guo… - Nature …, 2021 - nature.com
Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-
restricted epigenetic and transcriptional regulatory networks. Here, by integrating super …

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies

NS Nielsen, ET Poulsen, MV Lukassen… - Progress in Retinal and …, 2020 - Elsevier
Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI

SG Lee, JS Kim, HJ Kim, DD Schlaepfer, IS Kim… - Scientific reports, 2021 - nature.com
Several studies have suggested that extracellular matrix (ECM) remodeling and the
microenvironment are tightly associated with adipogenesis and adipose angiogenesis. In …

Classic lattice corneal dystrophy: a brief review and summary of treatment modalities

E Milovanova, S Gomon, G Rocha - Graefe's Archive for Clinical and …, 2024 - Springer
Purpose To provide a brief summary and comparison of the most recent literature on
available and theorized treatment modalities for classic lattice corneal dystrophy (LCD). This …

Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp

A Venkatraman, E Murugan, SJ Lin, GSL Peh… - Scientific Reports, 2020 - nature.com
Protein aggregation has been one of the leading triggers of various disease conditions, such
as Alzheimer's, Parkinson's and other amyloidosis. TGFBI-associated corneal dystrophies …

MARCHF8-mediated ubiquitination via TGFBI regulates NF-κB dependent inflammatory responses and ECM degradation in intervertebral disc degeneration

X Zhang, G Li, F Tan, T Yu, C Xu, K Li, F Zhang… - PloS one, 2025 - journals.plos.org
Aim To explore the role of the hub gene Transforming Growth Factor Beta Induced (TGFBI)
in Intervertebral disc degeneration (IDD) pathogenesis and its regulatory relationship with …

[HTML][HTML] Proteomic analysis of autoimmune retinopathy implicates neuronal cell adhesion molecule as a potential biomarker

A Al-Moujahed, G Velez, JT Vu, JRL de Carvalho… - Ophthalmology …, 2022 - Elsevier
Purpose To identify vitreous molecular biomarkers associated with autoimmune retinopathy
(AIR). Design Case-control study. Participants We analyzed 6 eyes from 4 patients …