[HTML][HTML] Signalling dynamics, cell decisions, and homeostatic control in health and disease
PO Valls, A Esposito - Current Opinion in Cell Biology, 2022 - Elsevier
Cell signalling engenders cells with the capability to receive and process information from
the intracellular and extracellular environments, trigger and execute biological responses …
the intracellular and extracellular environments, trigger and execute biological responses …
Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems
Technological advances have driven many recent advances in developmental biology. Light
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …
sheet imaging can reveal single-cell dynamics in living three-dimensional tissues, whereas …
In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning
Y Xu, B Wang, I Bush, HAJ Saunders, J Wildonger… - Science …, 2024 - science.org
During animal development, the spatiotemporal properties of molecular events largely
determine the biological outcomes. Conventional gene analysis methods lack the …
determine the biological outcomes. Conventional gene analysis methods lack the …
Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two-and three-dimensional tissue cultures
Recent advances in tissue engineering have been remarkable, yet the precise control of
cellular behavior in 2D and 3D cultures remains challenging. One approach to address this …
cellular behavior in 2D and 3D cultures remains challenging. One approach to address this …
Image-guided optogenetic spatiotemporal tissue patterning using μPatternScope
S Kumar, HM Beyer, M Chen, MD Zurbriggen… - Nature …, 2024 - nature.com
In the field of tissue engineering, achieving precise spatiotemporal control over engineered
cells is critical for sculpting functional 2D cell cultures into intricate morphological shapes. In …
cells is critical for sculpting functional 2D cell cultures into intricate morphological shapes. In …
Rapid and reversible dissolution of biomolecular condensates using light-controlled recruitment of a solubility tag
Biomolecular condensates are broadly implicated in both normal cellular regulation and
disease. Consequently, several chemical biology and optogenetic approaches have been …
disease. Consequently, several chemical biology and optogenetic approaches have been …
Platforms for optogenetic stimulation and feedback control
S Kumar, M Khammash - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Harnessing the potential of optogenetics in biology requires methodologies from different
disciplines ranging from biology, to mechatronics engineering, to control engineering. Light …
disciplines ranging from biology, to mechatronics engineering, to control engineering. Light …
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture
In embryonic stem cell (ESC) models for early development, spatially and temporally varying
patterns of signaling and cell types emerge spontaneously. However, mechanistic insight …
patterns of signaling and cell types emerge spontaneously. However, mechanistic insight …
Optogenetic control of YAP cellular localisation and function
PJY Toh, JKH Lai, A Hermann, O Destaing… - EMBO …, 2022 - embopress.org
YAP, an effector of the Hippo signalling pathway, promotes organ growth and regeneration.
Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore …
Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore …
Design and engineering of light-sensitive protein switches
Engineered, light-sensitive protein switches are used to interrogate a broad variety of
biological processes. These switches are typically constructed by genetically fusing naturally …
biological processes. These switches are typically constructed by genetically fusing naturally …