The cause of Parkinson's disease (PD) remains unknown in most patients. Since 1997, with
the first genetic mutation known to cause PD described in SNCA gene, many other genes …

Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Rare mutations in genes originally discovered in multigenerational families have been
associated with increased risk of Parkinson's disease (PD). The involvement of rare variants …

Although originally multi-ethnic in its structure, nowadays the Calabria region of southern
Italy represents an area with low genetic heterogeneity and a high level of consanguinity …

Parkinson's disease (PD) is characterized by the accumulation of misfolded α-synuclein (α-
syn). Promoting the degradation of misfolded proteins has been shown to be an effective …

PD is a prevalent and progressive neurodegenerative disorder characterized by both motor
and non-motor symptoms. Genes play a significant role in the onset and progression of the …

PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24–32
nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs …

Autophagosomes fuse with lysosomes, forming autolysosomes that degrade engulfed cargo.
To maintain lysosomal capacity, autolysosome reformation (ALR) must regenerate …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative disorders. Pathologically, AD and PD are characterized by the …