Histone acetylation is highly conserved across eukaryotes and has been linked to gene
activation since its discovery nearly 60 years ago. Over the past decades, histone …

In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the
activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the …

Acetylation of histones is a key post-translational modification that guides gene expression
regulation. In yeast, the class I histone deacetylase containing Rpd3S complex plays a …

The Rpd3S complex plays a pivotal role in facilitating local histone deacetylation in the
transcribed regions to suppress intragenic transcription initiation. Here, we present the cryo …

Histones are subject to a diverse array of post-translational modifications. Among them,
lysine acetylation is not only the most pervasive and dynamic modification but also highly …

In Saccharomyces cerevisiae, the Rpd3L complex includes the histone deacetylase Rpd3
and the DNA binding proteins Ume6 and Ash1 and serves as a transcriptional silencer or …

The Rpd3 histone deacetylase complex is a multiple-subunit complex that mediates the
regulation of chromatin accessibility and gene expression. Sin3, the largest subunit of Rpd3 …

I 型组蛋白去乙酰化酶复合物是从酵母到人所有真核生物中都保守的依赖于锌离子的组蛋白修饰
酶. 酿酒酵母Rpd3S 和裂殖酵母来源同系物Clr6S 包含多个亚基, 可以被甲基化修饰的组蛋白H3 …

SIN3 is a constitutive regulator that controls metabolic genes and pathways by effecting the
post translational modification profile of histone tails. SIN3 directly binds and regulates many …