The genomic health of human pluripotent stem cells: genomic instability and the consequences on nuclear organization

MP Henry, JR Hawkins, J Boyle, JM Bridger - Frontiers in genetics, 2019 - frontiersin.org
Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative
therapies worldwide, with embryonic and induced pluripotent stem cells as potential …

Landscape and significance of human super enhancer-driven core transcription regulatory circuitry

C Feng, C Song, Y Jiang, J Zhao, J Zhang… - … Therapy-Nucleic Acids, 2023 - cell.com
A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry
that is formed by a group of core transcription factors (TFs). These core TFs collectively …

GWAS of reproductive traits in Large White pigs on chip and imputed whole-genome sequencing data

X Wang, L Wang, L Shi, P Zhang, Y Li, M Li… - International Journal of …, 2022 - mdpi.com
Total number born (TNB), number of stillborn (NSB), and gestation length (GL) are
economically important traits in pig production, and disentangling the molecular …

Expression patterns of circular RNAs in high quality and poor quality human spermatozoa

T Chioccarelli, F Manfrevola, B Ferraro… - Frontiers in …, 2019 - frontiersin.org
Circular RNAs (circRNAs) are expressed in human testis and seminal plasma. Until today,
there is missing information about a possible payload of circRNAs in human spermatozoa …

The single-cell expression profile of transposable elements and transcription factors in human early biparental and uniparental embryonic development

C Li, Y Zhang, L Leng, X Pan, D Zhao, X Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Transposable elements (TEs) and transcription factors (TFs) are involved in the precise
regulation of gene expression during the preimplantation stage. Activation of TEs is a key …

[HTML][HTML] Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium

AM Kelleher, SK Behura, GW Burns, SL Young… - The FASEB …, 2019 - ncbi.nlm.nih.gov
The pioneer forkhead box (FOX) A2 transcription factor is specifically expressed in the
glands of the uterus, which are central to endometrial function and fertility. In mice, FOXA2 is …

A comparative analysis of single-cell transcriptome identifies reprogramming driver factors for efficiency improvement

H Li, M Song, W Yang, P Cao, L Zheng… - Molecular Therapy-Nucleic …, 2020 - cell.com
Terminally differentiated somatic cells can be reprogrammed into a totipotent state through
somatic cell nuclear transfer (SCNT). The incomplete reprogramming is the major reason for …

The dynamic changes of transcription factors during the development processes of human biparental and uniparental embryos

C Zhang, C Li, L Yang, L Leng, D Jovic… - Frontiers in Cell and …, 2021 - frontiersin.org
Previous studies have revealed that transcription factors (TFs) play important roles in
biparental (BI) early human embryogenesis. However, the contribution of TFs during early …

Sperm cryopreservation impacts the early development of equine embryos by downregulating specific transcription factors

JM Ortiz-Rodríguez, FE Martín-Cano FE… - BioRxiv, 2021 - biorxiv.org
Equine embryos were obtained by insemination with either fresh or frozen-thawed
spermatozoa at 8, 10 and 12 h post spontaneous ovulation, maintaining the pairs mare …

Single-cell RNA sequencing reveals abnormal fluctuations in human eight-cell embryos associated with blastocyst formation failure

QL He, P Yuan, L Yang, ZQ Yan, W Chen… - Molecular Human …, 2022 - academic.oup.com
Infertility has become a global health issue, with the number of people suffering from the
disease increasing year by year, and ART offering great promise for infertility treatment …