Liver fibrosis: Direct antifibrotic agents and targeted therapies
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …
patients with chronic liver disease. Their prevention or reversal have become major …
Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases
The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …
in composition, form, and functionality over time. The stochasticity begins during …
Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations
Protein thermodynamics is intimately tied to biological function and can enable processes
such as signal transduction, enzyme catalysis, and molecular recognition. The relative free …
such as signal transduction, enzyme catalysis, and molecular recognition. The relative free …
[HTML][HTML] DDR1 role in fibrosis and its pharmacological targeting
S Moll, A Desmoulière, MJ Moeller, JC Pache… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Abstract Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …
and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located …
Discoidin domain receptor 1 mediates myosin-dependent collagen contraction
NM Coelho, PD Arora, S van Putten, S Boo, P Petrovic… - Cell reports, 2017 - cell.com
Summary Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion
receptor that mediates cell migration through association with non-muscle myosin IIA …
receptor that mediates cell migration through association with non-muscle myosin IIA …
[HTML][HTML] Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
J Wang, S Xie, N Li, T Zhang, W Yao, H Zhao, W Pang… - Bioactive Materials, 2022 - Elsevier
Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …
response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be …
[HTML][HTML] The basement membrane in the cross-roads between the lung and kidney
The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …
plays a central role in maintaining lung and kidney functions. Although the composition of …
Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer's …
Abstract Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine
kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals …
kinase inhibitor that is FDA-approved for leukemia and potently inhibits DDR-1. Individuals …
The role of basement membranes in cardiac biology and disease
E Boland, F Quondamatteo… - Bioscience Reports, 2021 - portlandpress.com
Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures
that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and …
that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and …
Renal fibrosis: recent translational aspects
H François, C Chatziantoniou - Matrix Biology, 2018 - Elsevier
Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …
to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of …