Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Inflammatory demyelinating diseases (IDDs) are among the main causes of inflammatory
and neurodegenerative injury of the central nervous system (CNS) in young adult patients …

Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates signal
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …

In recent years, epigenetic modifications have been widely researched. As humans age,
environmental and genetic factors may drive inflammation and immune responses by …

Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause
of transfusion-associated death. Its poor associated prognosis is due, in large part, to the …

The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …

The flow of substances between the blood and the central nervous system is precisely
regulated by the blood–brain barrier (BBB). Its disruption due to unbalanced blood glucose …

The morbidity and mortality of cancer are rising rapidly worldwide and immunotherapy has
become an effective means to curb the progress of cancer. Sirtuin-1 (SIRT1) is a NAD+ …

Multiple sclerosis (MS) is a chronic disease that is characterized by demyelination and
neuronal damage. Experimental autoimmune encephalomyelitis (EAE) mice are used to …

Background and objectives Multiple sclerosis (MS) is a chronic, progressive neurological
disease characterized by early-stage neuroinflammation, neurodegeneration, and …