Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Telomerase reverse transcriptase (TERT) promoter mutation has been reported to be
associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study …

Background The association between telomerase reverse transcriptase (TERT) promoter
mutations and some clinical behaviors in thyroid cancer remains controversial and requires …

Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland, with
a relatively high cure rate. Distant metastasis (DM) of PTC is uncommon, but when it occurs …

Background: The BRAFV600E mutation in papillary thyroid carcinoma (PTC) is particularly
prevalent in Korea, and a considerable number of wild-type BRAF PTCs harbor RAS …

The prognostic role of molecular markers in papillary thyroid carcinoma (PTC) is a matter of
ongoing debate. The aim of our study is to investigate the impact of RAS, BRAF, TERT …