Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

MicroRNA-19a-3p inhibits endothelial dysfunction in atherosclerosis by targeting JCAD

J Luo, L Wang, C Cui, H Chen, W Zeng, X Li - BMC Cardiovascular …, 2024 - Springer
Objective To examine the influences and mechanisms of MicroRNA-19a-3p (miR-19a-3p)
on endothelial dysfunction in atherosclerosis. Methods An analysis of miR-19a expression …

[HTML][HTML] JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis

L Xie, H Chen, L Zhang, Y Ma, Y Zhou… - Clinical and …, 2024 - ncbi.nlm.nih.gov
Methods Serial sections of liver tissue of PBC patients were stained with
immunofluorescence. Hepatic fibrosis was induced by bile duct ligation (BDL) in wild-type …

JCAD deficiency delayed liver regenerative repair through the Hippo–YAP signalling pathway

L Zhang, YY Yang, L Xie, Y Zhou… - Clinical and …, 2024 - Wiley Online Library
Background and aims Liver regeneration retardation post partial hepatectomy (PH) is a
common clinical problem after liver transplantation. Identification of key regulators in liver …

[HTML][HTML] Research Progress and Clinical Translation Potential of Coronary Atherosclerosis Diagnostic Markers from a Genomic Perspective

H Liu, Y Zhang, Y Zhao, Y Li, X Zhang, L Bao, R Yan… - Genes, 2025 - mdpi.com
Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid
deposition, chronic inflammation, and fibrous tissue proliferation, leading to arterial wall …

Combining systems pharmacology, metabolomics, and transcriptomics to reveal the mechanism of Salvia miltiorrhiza-Cortex moutan herb pair for the treatment of …

C Zhao, X Bai, Y Ding, A Wen, Q Fu - Frontiers in Pharmacology, 2024 - frontiersin.org
Ischemic stroke (IS), predominantly triggered by blockages in cerebral blood flow, is
increasingly recognized as a critical public health issue. The combination of Salvia …

[HTML][HTML] Endothelial H2S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis

X Chen, H Wang, C Wu, X Li, X Huang, Y Ren, Q Pu… - Redox Biology, 2024 - Elsevier
Dysfunction of the vascular angiocrine system is critically involved in regenerative defects
and fibrosis of injured organs. Previous studies have identified various angiocrine factors …

Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet

W Yang, R Feng, G Peng, Z Wang, M Cen… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: Glycoursodeoxycholic acid (GUDCA) has been acknowledged for its ability
to regulate lipid homeostasis and provide benefits for various metabolic disorders. However …

[HTML][HTML] Hutchinson-Gilford progeria syndrome mice display accelerated arterial thrombus formation and increased platelet reactivity

YM Puspitasari, S Ministrini, J Han, C Karch… - Thrombosis …, 2024 - Elsevier
Abstract Introduction Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare
premature aging genetic disorder caused by a point mutation in the lamin A gene, LMNA …

Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9–CXCR3 axis

L Yao, L Qu, J Deng, C Zhu, R Fu, M Jiang… - Food Frontiers, 2024 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF), often likened to a “tumor‐like disease,” proves more
lethal than several malignancies. Although prior studies have demonstrated the lung …