Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration
D Križaj, S Cordeiro, O Strauß - Progress in Retinal and eye Research, 2023 - Elsevier
Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …
The transduction cascade in retinal ON-bipolar cells: signal processing and disease
KA Martemyanov, AP Sampath - Annual review of vision …, 2017 - annualreviews.org
Our robust visual experience is based on the reliable transfer of information from our
photoreceptor cells, the rods and cones, to higher brain centers. At the very first synapse of …
photoreceptor cells, the rods and cones, to higher brain centers. At the very first synapse of …
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
The extent and temporal characteristics of G protein–coupled receptor (GPCR) signaling are
shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein …
shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein …
Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons
Y Cao, J Pahlberg, I Sarria… - Proceedings of the …, 2012 - National Acad Sciences
The time course of signaling via heterotrimeric G proteins is controlled through their
activation by G-protein coupled receptors and deactivation through the action of GTPase …
activation by G-protein coupled receptors and deactivation through the action of GTPase …
RGS6 as a novel therapeutic target in CNS diseases and cancer
Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular
responses induced by G protein-coupled receptor (GPCR)-mediated activation of …
responses induced by G protein-coupled receptor (GPCR)-mediated activation of …
Critical role for phosphatidylinositol-3 kinase Vps34/PIK3C3 in ON-bipolar cells
F He, RM Nichols, L Kailasam… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: Phosphatidylinositol-3-phosphate (PI (3) P), and Vps34, the type III
phosphatidylinositol 3-kinase primarily responsible for its production, are important for …
phosphatidylinositol 3-kinase primarily responsible for its production, are important for …
Protein profiling of RGS6, a pleiotropic gene implicated in numerous neuropsychiatric disorders, reveals multi-isoformic expression and a novel brain-specific isoform
KE Ahlers-Dannen, J Yang, MM Spicer, B Maity… - Eneuro, 2022 - eneuro.org
A metanalysis identified regulator of G-protein signaling 6 (RGS6) as one of 23 loci with
pleiotropic effects on four or more human psychiatric disorders. This finding is significant as …
pleiotropic effects on four or more human psychiatric disorders. This finding is significant as …
Mouse b-wave mutants
MT Pardue, NS Peachey - Documenta Ophthalmologica, 2014 - Springer
The b-wave is a major component of the electroretinogram that reflects the activity of
depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with …
depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with …
Gβ3 is required for normal light ON responses and synaptic maintenance
A Dhingra, H Ramakrishnan, A Neinstein… - Journal of …, 2012 - Soc Neuroscience
Heterotrimeric G-proteins, comprising Gα and Gβγ subunits, couple metabotropic receptors
to various downstream effectors and contribute to assembling and trafficking receptor-based …
to various downstream effectors and contribute to assembling and trafficking receptor-based …
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice
Two members of the R7 subfamily of regulators of G protein signaling, RGS7 and RGS11,
are present at dendritic tips of retinal depolarizing bipolar cells (DBCs). Their involvement in …
are present at dendritic tips of retinal depolarizing bipolar cells (DBCs). Their involvement in …