Condensins are multisubunit protein complexes that play a fundamental role in the structural
and functional organization of chromosomes in the three domains of life. Most eukaryotic …

Cell death programs are major players in tissue homeostasis, development and cellular
stress responses. A prominent cause of malignant transformation is the cumulative genetic …

Abstract The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid
malignancies such as chronic lymphocytic leukemia (CLL), T-prolymphocytic leukemia (T …

In addition to allelic mutations, cancers are known to harbor alterations in their chromatin
landscape. Here we show that genomic ablation of Smad ubiquitin regulatory factor 2 …

Introduction Radiotherapy, like most anticancer treatments, achieves its therapeutic effect by
inducing different types of cell death in tumors. Cell death markers and imaging modalities …

The spindle checkpoint that monitors kinetochore–microtubule attachment has been
implicated in tumorigenesis; however, the relation between the spindle checkpoint and cell …

A‐lamins, encoded by the LMNA gene, are major structural components of the nuclear
lamina coordinating essential cellular processes. Mutations in the LMNA gene and/or …

The use of whole-exome and whole-genome sequencing has been a catalyst for a genotype-
first approach to diagnostics. Under this paradigm, we have implemented systematic …

ABSTRACT E1B-55K-associated protein 5 (E1B-AP5) is a cellular, heterogeneous nuclear
ribonucleoprotein that is targeted by adenovirus (Ad) E1B-55K during infection. The function …

Background Photon (X‐ray) radiotherapy (XRT) kills cells via DNA damage, however, how
proton radiotherapy (PRT) causes cell death in head and neck squamous cell carcinoma …