Cancer stem cells: the architects of the tumor ecosystem
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …
Cancer stem cells: The root of tumor recurrence and metastases
C Peitzsch, A Tyutyunnykova, K Pantel… - Seminars in cancer …, 2017 - Elsevier
Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …
formation can be considered as a culmination of the Darwinian evolutionary process within …
Tissue mechanics in stem cell fate, development, and cancer
Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …
development and homeostasis. Cells sense mechanical cues through localized …
Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
T Celià-Terrassa, MK Jolly - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to
initiate heterogeneous tumors. It is also relevant in metastasis and can explain how …
initiate heterogeneous tumors. It is also relevant in metastasis and can explain how …
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
The sub-population of tumor cells termed 'cancer stem cells'(CSCs) possess the capability to
generate tumors, undergo epithelial–mesenchymal transition (EMT) and are implicated in …
generate tumors, undergo epithelial–mesenchymal transition (EMT) and are implicated in …
Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
S Kasimir-Bauer, O Hoffmann, D Wallwiener… - Breast Cancer …, 2012 - Springer
Introduction The presence of circulating tumor cells (CTC) in breast cancer might be
associated with stem cell-like tumor cells which have been suggested to be the active …
associated with stem cell-like tumor cells which have been suggested to be the active …
CD44+/CD24−/low cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome
MO Idowu, M Kmieciak, C Dumur, RS Burton… - Human pathology, 2012 - Elsevier
Women classified as having triple-negative tumors have a poor prognosis. The importance
of CD44+/CD24−/low (stem/progenitor cell-phenotype) in breast cancer patients has also …
of CD44+/CD24−/low (stem/progenitor cell-phenotype) in breast cancer patients has also …
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab
Although current breast cancer treatment guidelines limit the use of HER2-blocking agents
to tumors with HER2 gene amplification, recent retrospective analyses suggest that a wider …
to tumors with HER2 gene amplification, recent retrospective analyses suggest that a wider …
Epithelial–mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
Currently, there is extensive information about circulating tumor cells (CTC) and their
prognostic value; however, little is known about other characteristics of these cells. In this …
prognostic value; however, little is known about other characteristics of these cells. In this …
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids
S Condello, CA Morgan, S Nagdas, L Cao, J Turek… - Oncogene, 2015 - nature.com
Cancer cells form three-dimensional (3D) multicellular aggregates (or spheroids) under non-
adherent culture conditions. In ovarian cancer (OC), spheroids serve as a vehicle for cancer …
adherent culture conditions. In ovarian cancer (OC), spheroids serve as a vehicle for cancer …