The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of autosomal
dominantly inherited progressive disorders, the clinical hallmark of which is loss of balance …

Several hereditary neurological and neuromuscular diseases are caused by an abnormal
expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat …

Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …

The aggregation of polyglutamine (polyQ)-containing proteins is at the origin of nine
neurodegenerative diseases. Molecular chaperones prevent the aggregation of polyQ …

Protein A, a major cell wall component of Staphylococcus aureus, is one of the first
immunoglobulin-binding proteins that is discovered about 80 years ago. However, a great …

Proteins containing glutamine repeats (polyQ) are known to be structurally unstable.
Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to …

The polyglutamine (polyQ) diseases consist of nine neurodegenerative diseases in which a
polyQ tract expansion leads to protein misfolding and subsequent aggregation. Even when …

Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in
several neurological disorders, being directly involved in the molecular mechanisms …

Small heat-shock proteins (sHsps) are molecular chaperones that play an important
protective role against cellular protein misfolding by interacting with partially unfolded …

Currently, nine polyglutamine (polyQ) expansion diseases are known. They include
spinocerebellar ataxias (SCA1, 2, 3, 6, 7, 17), spinal and bulbar muscular atrophy (SBMA) …