Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Bacterial antibiotic resistance, especially the emergence of multidrug-resistant (MDR)
strains, urgently requires the development of effective treatment strategies. It is always of …

Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or
prevention of several neurogenerative diseases. However, CB2 agonists, particularly …

Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

Streptococcus mutans is a Gram-positive bacterium highly associated with dental caries,
and it has a strong biofilm-forming ability, especially in a sugar-rich environment. Many …

The rise of antimicrobial resistance is a global public health crisis that threatens the effective
control and prevention of infections. Due to the emergence of pandrug-resistant bacteria …

This untargeted metabolomics study investigated the synergistic antibacterial activity of
polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis …

Colistin-and carbapenem-resistant Acinetobacter baumannii is a serious multidrug resistant
(MDR) bacterium in clinical settings. Discovery of new antibacterial drugs against MDR is …

In the scenario of fighting bacterial resistance to antibiotics, natural products have been
extensively investigated for their potential antibacterial activities. Among these …

Here, we employed an integrated metabolomics and transcriptomics approach to investigate
the molecular mechanism (s) of action of ceftazidime/avibactam against a pan-drug-resistant …