Systems biology of stem cell fate and cellular reprogramming
BD MacArthur, A Ma'ayan, IR Lemischka - Nature reviews Molecular …, 2009 - nature.com
Stem cell differentiation and the maintenance of self-renewal are intrinsically complex
processes requiring the coordinated dynamic expression of hundreds of genes and proteins …
processes requiring the coordinated dynamic expression of hundreds of genes and proteins …
The current state of chromatin immunoprecipitation
P Collas - Molecular biotechnology, 2010 - Springer
The biological significance of interactions of nuclear proteins with DNA in the context of
gene expression, cell differentiation, or disease has immensely been enhanced by the …
gene expression, cell differentiation, or disease has immensely been enhanced by the …
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
Epigenetic regulators represent a promising new class of therapeutic targets for cancer.
Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2) …
Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2) …
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
J Schödel, S Oikonomopoulos… - Blood, The Journal …, 2011 - ashpublications.org
Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia.
To better understand this transcriptional cascade we performed genome-wide chromatin …
To better understand this transcriptional cascade we performed genome-wide chromatin …
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
The capacity to fine-tune cellular bioenergetics with the demands of stem-cell maintenance
and regeneration is central to normal development and ageing, and to organismal survival …
and regeneration is central to normal development and ageing, and to organismal survival …
An integrated software system for analyzing ChIP-chip and ChIP-seq data
We present CisGenome, a software system for analyzing genome-wide chromatin
immunoprecipitation (ChIP) data. CisGenome is designed to meet all basic needs of ChIP …
immunoprecipitation (ChIP) data. CisGenome is designed to meet all basic needs of ChIP …
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
In embryonic stem (ES) cells, a well-characterized transcriptional network promotes
pluripotency and represses gene expression required for differentiation. In comparison, the …
pluripotency and represses gene expression required for differentiation. In comparison, the …
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity
in the vertebrate limb. We characterized the Gli-dependent cis-regulatory network through a …
in the vertebrate limb. We characterized the Gli-dependent cis-regulatory network through a …
REST–mediated recruitment of Polycomb repressor complexes in mammalian cells
N Dietrich, M Lerdrup, E Landt, S Agrawal-Singh… - PLoS …, 2012 - journals.plos.org
Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in
differentiation and development. However, the mechanism for how PRC1 and PRC2 are …
differentiation and development. However, the mechanism for how PRC1 and PRC2 are …