Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives
cancer progression, although the pathways of tumour cell dissemination are unclear. Here …

A series of sulfonamide-containing 1, 5-diarylpyrazole derivatives were prepared and
evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive …

Eicosanoids represent a diverse family of lipid mediators with fundamental roles in
physiology and disease. Within the eicosanoid superfamily are prostanoids, which are …

Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized
classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting …

One hundred years have passed since Felix Hoffman, working at Bayer Industries, reported
the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug …

Within the vast range of heterocycles, benzimidazole and its derivatives are found to be
trendy structures employed for discovery of drugs in the field of pharmaceutical and …

Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

Results from our previous studies demonstrated that activation of Toll-like receptor 4 (Tlr4),
the lipopolysaccharide (LPS) receptor, is sufficient to induce nuclear factor κB activation and …