Nickel impact on human health: An intrinsic disorder perspective
The interplay of the presence of nickel and protein disorder in processes affecting human
health is the focus of the present review. Many systems involving nickel as either a cofactor …
health is the focus of the present review. Many systems involving nickel as either a cofactor …
Not an exception to the rule: the functional significance of intrinsically disordered protein regions in enzymes
S DeForte, VN Uversky - Molecular BioSystems, 2017 - pubs.rsc.org
Intrinsically disordered protein regions (IDPRs) are remarkably common and have unique
and important biological functions. Enzymes have long been considered an exception to the …
and important biological functions. Enzymes have long been considered an exception to the …
Highly disordered proteins in prostate cancer
Prostate cancer is one of the major threats to the man's health. There are several
mechanisms of the prostate cancer development characterized by the involvement of …
mechanisms of the prostate cancer development characterized by the involvement of …
Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells
Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger
genetic elements, including" all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as …
genetic elements, including" all-in-one" CRISPR/Cas9 plasmids, but is limited by toxicity as …
Autoantibodies directed toward a novel IA-2 variant protein enhance prediction of type 1 diabetes
MJ Acevedo-Calado, SL Pietropaolo, MP Morran… - Diabetes, 2019 - Am Diabetes Assoc
We identified autoantibodies (AAb) reacting with a variant IA-2 molecule (IA-2var) that has
three amino acid substitutions (Cys27, Gly608, and Pro671) within the full-length molecule …
three amino acid substitutions (Cys27, Gly608, and Pro671) within the full-length molecule …
A collection of intrinsic disorder characterizations from eukaryotic proteomes
Intrinsically disordered proteins and protein regions lack a stable three-dimensional
structure under physiological conditions. Several proteomic investigations of intrinsic …
structure under physiological conditions. Several proteomic investigations of intrinsic …
On the need to develop guidelines for characterizing and reporting intrinsic disorder in proteins
Since the early 2000s, numerous computational tools have been created and used to predict
intrinsic disorder in proteins. At present, the output from these algorithms is difficult to …
intrinsic disorder in proteins. At present, the output from these algorithms is difficult to …
Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer
Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly
prevalent among men. The number of studies focused on the abundance and roles of …
prevalent among men. The number of studies focused on the abundance and roles of …
Disorder Atlas: Web-based software for the proteome-based interpretation of intrinsic disorder predictions
Intrinsically disordered proteins lack a stable three-dimensional structure under
physiological conditions. While this property has gained considerable interest within the past …
physiological conditions. While this property has gained considerable interest within the past …
Dysregulation of redox processes in the placenta during its dysfunction
TN Pogorelova, VO Gunko, AA Nikashina… - Проблемы …, 2019 - elibrary.ru
Цель исследования-изучить плацентарную активность про-и антиоксидантных
ферментов, а также оценить экспрессию белков, регулирующих окислительно …
ферментов, а также оценить экспрессию белков, регулирующих окислительно …