DNA-encoded chemical libraries
AL Satz, A Brunschweiger, ME Flanagan… - Nature Reviews …, 2022 - nature.com
DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to
discover small molecules capable of modulating biologically relevant targets. DECL …
discover small molecules capable of modulating biologically relevant targets. DECL …
DNA-encoded chemistry: enabling the deeper sampling of chemical space
RA Goodnow Jr, CE Dumelin, AD Keefe - Nature Reviews Drug …, 2017 - nature.com
DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …
DNA-encoded chemistry: drug discovery from a few good reactions
PR Fitzgerald, BM Paegel - Chemical reviews, 2020 - ACS Publications
Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by
empowering combinatorial library synthesis with a “few good reactions”. These click …
empowering combinatorial library synthesis with a “few good reactions”. These click …
Open-air alkylation reactions in photoredox-catalyzed DNA-encoded library synthesis
DNA-encoded library (DEL) technology is a powerful tool commonly used by the
pharmaceutical industry for the identification of compounds with affinity to biomolecular …
pharmaceutical industry for the identification of compounds with affinity to biomolecular …
Combinatorial chemistry in drug discovery
Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …
A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition
DNA-encoded chemical libraries (DELs) consist of large chemical compound collections
individually linked to DNA barcodes, facilitating pooled construction and screening …
individually linked to DNA barcodes, facilitating pooled construction and screening …
[HTML][HTML] The expanding reaction toolkit for DNA-encoded libraries
RJ Fair, RT Walsh, CD Hupp - Bioorganic & Medicinal Chemistry Letters, 2021 - Elsevier
Over the past decade, DNA-encoded libraries (DELs) have emerged as a leading platform
for small molecule drug discovery among pharmaceutical companies, biotech companies …
for small molecule drug discovery among pharmaceutical companies, biotech companies …
Chemical space of DNA-encoded libraries: Miniperspective
RM Franzini, C Randolph - Journal of medicinal chemistry, 2016 - ACS Publications
In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …
attention as a potential discovery tool in drug development. Screening encoded libraries …
DNA-encoded library screening as core platform technology in drug discovery: its synthetic method development and applications in DEL synthesis
DNA-encoded library technology (DELT) was introduced to our medicinal chemistry society
more than 20 years ago. The application of DELT in the development of clinical candidates …
more than 20 years ago. The application of DELT in the development of clinical candidates …
Machine learning on DNA-encoded libraries: a new paradigm for hit finding
K McCloskey, EA Sigel, S Kearnes, L Xue… - Journal of Medicinal …, 2020 - ACS Publications
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for
many distinct protein targets of therapeutic value. We demonstrate a new approach applying …
many distinct protein targets of therapeutic value. We demonstrate a new approach applying …