Background Use of an interferon-γ (IFN-γ) release assay or tuberculin skin test for detection
and management of latent tuberculosis infection is controversial. For both types of test, we …

Background An estimated one fourth of the world's population is infected with
Mycobacterium tuberculosis, and 5–10% of those infected develop tuberculosis in their …

Little is known about the physiology of latent Mycobacterium tuberculosis infection. We
studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected …

Since the introduction of biologics for the treatment of rheumatoid arthritis (RA), psoriatic
arthritis (PsA), ankylosing spondylitis (AS), and psoriasis (Pso) an increased risk of …

Background Timely and accurate identification of people with latent tuberculosis infection
(LTBI) is important for controlling Mycobacterium tuberculosis (TB). There is no gold …

The link between chronic kidney disease (CKD) and tuberculosis (TB) has been known for
more than 40 years, but the interaction between these 2 diseases is still poorly understood …

Background Evidence on the comparative performance of purified protein derivative
tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) for predicting …

Mycobacterial infections, both tuberculosis and nontuberculous, are more common in
patients with haematological malignancies and haematopoietic stem cell transplant …

New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools
for diagnosis and new biomarkers are required to evaluate both pathogen and host key …

Background Tuberculosis preventive therapy (TPT) reduces TB-related morbidity and
mortality in people living with HIV (PLHIV). Cascade-of-care analyses help identify gaps and …