The identification of MPTP, a relatively simple compound which causes selective
degeneration of the substantia nigra after systemic administration, has had an a significant …

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates,
suggesting an intimate connection between injured brain and loss of proteostasis …

Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …

Synucleinopathies are a group of neurodegenerative diseases characterized by the
accumulation of α-synuclein aggregates in neurons, nerve fibers or glial cells. Three main …

Scope and application: The present review focuses on the innovative extraction and
encapsulation methods of the phytochemical constituents from various parts of saffron plant …

Recent evidence demonstrates that Crocus sativus L.(saffron) counteracts oxidative stress,
mitochondrial dysfunction and neuroinflammation, closely linked to initiation and …

Transcranial photobiomodulation (PBM), which involves the application of low-intensity red
to near-infrared light (600–1100 nm) to the head, provides neuroprotection in animal models …

Saffron, indicated as “the red gold,” is an extraordinary spice with a unique aroma and
organoleptic properties that is largely diffused in food preparation as well as a traditional …

Background It is established that natural medicines for Parkinson's disease (PD) provide an
antioxidant activity in preventing dopaminergic neurons from degeneration. However, the …

Intensive screening for better and safer medications to treat diseases such as cancer and
inflammatory diseases continue, and some phytochemicals have been discovered to have …