Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to
increased protein and DNA modification contributing to cell and tissue dysfunction in aging …

In recent years, glycative stress from exogenous or endogenous advanced glycation end
products (AGEs) and highly reactive dicarbonyls has gained great attention for its putative …

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal
(MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced …

Cancer is a disease characterised by uncontrolled growth and proliferation of cells. Tumours
primarily show a higher rate of glucose uptake for lactate production even in the presence of …

Abstract Glyoxalase 1 (Glo1) is part of the glyoxalase system in the cytoplasm of all human
cells. It catalyses the glutathione-dependent removal of the endogenous reactive dicarbonyl …

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal
(MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly …

Background Breast cancer is a familiar malignant tumor, which is a great threat to women's
life. Long noncoding RNA Opa interacting protein 5-antisense RNA 1 (OIP5-AS1) has been …

Metastasis is the primary cause of death in prostate cancer (PC a) patients. Effective
therapeutic intervention in metastatic PC a is undermined by our poor understanding of its …

Emerging evidence indicates that methylglyoxal (MG) can inhibit tumorigenesis. Glyoxalase
I (GLOI), a MG degradation enzyme, is implicated in the progression of human malignancies …

Methylglyoxal (MG) is a dicarbonyl compound formed in cells mainly by the spontaneous
degradation of the triose phosphate intermediates of glycolysis. MG is a powerful precursor …