Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Ion channels are end-targets (effectors) in a large number of regulatory pathways that are
initiated by G-protein-coupled neurotransmitters and hormones. Modulation of ion channels …

Interactions between μ-opioid receptor (μOR) and cannabinoid CB1 receptor (CB1R) were
examined by morphological and electrophysiological methods. In baby hamster kidney …

GIRK (Kir3) channels are activated by neurotransmitters coupled to G proteins, via a direct
binding of G βγ. The role of Gα subunits in GIRK gating is elusive. Here we demonstrate that …

Depression and anxiety disorders are highly prevalent. Selective serotonin reuptake
inhibitors (SSRIs) are the current first-line treatment for depression, but they have …

G-protein coupled receptors are not considered to exhibit voltage sensitivity. Here, using
Xenopus oocytes, we show that the M 2 muscarinic receptor (m2R) is voltage-sensitive. The …

Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.
Almost 20 years ago, GPCR activity was shown to be regulated by membrane potential in …

Muscarinic receptors are G protein-coupled receptors (GPCRs) that play a role in various
physiological functions. Previous studies have shown that these receptors, along with other …

G protein-activated K+ channels (GIRKs; Kir3) are activated by direct binding of Gβγ
subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin …