The Dysferlinopathies Conundrum: Clinical Spectra, Disease Mechanism and Genetic Approaches for Treatments

S Anwar, T Yokota - Biomolecules, 2024 - mdpi.com
Dysferlinopathies refer to a spectrum of muscular dystrophies that cause progressive muscle
weakness and degeneration. They are caused by mutations in the DYSF gene, which …

Angiotensin II receptor blocker losartan exacerbates muscle damage and exhibits weak blood pressure-lowering activity in a dysferlin-null model of Limb-Girdle …

Z White, N Milad, AY Tehrani, WWH Chen, G Donen… - PLoS …, 2019 - journals.plos.org
There is no cure or beneficial management option for Limb-Girdle muscular dystrophy (MD)
type 2B (LGMD2B). Losartan, a blood pressure (BP) lowering angiotensin II (AngII) receptor …

Synthetic cannabinoid CP-55,940 induces apoptosis in a human skeletal muscle model via regulation of CB1 receptors and l-type Ca2+ channels

K Tomiyama, M Funada - Archives of Toxicology, 2021 - Springer
Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids.
However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of …

[HTML][HTML] Damaged muscle fibers might masquerade as hybrid fibers–a cautionary note on immunophenotyping mouse muscle with mouse monoclonal antibodies

M Begam, JA Roche - European Journal of Histochemistry: EJH, 2018 - ncbi.nlm.nih.gov
We report that, labeling mouse muscle tissue, with mouse monoclonal antibodies specific to
slow or fast myosin heavy chain (sMyHC and fMyHC, respectively), can lead to artefactual …

The effects of concentric and eccentric training in murine models of dysferlin‐associated muscular dystrophy

M Begam, R Roche, JJ Hass, CA Basel… - Muscle & …, 2020 - Wiley Online Library
Introduction Dysferlin‐deficient murine muscle sustains severe damage after repeated
eccentric contractions. Methods With a robotic dynamometer, we studied the response of …

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

M Begam, N Narayan, D Mankowski, R Camaj… - JoVE (Journal of …, 2022 - jove.com
Progressive resistance training (PRT), which involves performing muscle contractions
against progressively greater external loads, can increase muscle mass and strength in …

Minimally invasive muscle embedding generates donor-cell-derived muscle fibers that express desmin and dystrophin

JA Roche, M Begam, AK Eaton, CJ Elkins… - Military …, 2020 - academic.oup.com
Introduction The aim of this study was to quantify the extent of donor-cell-derived
myogenesis achieved by a novel surgical technique known as Minimally Invasive Muscle …

Влияние исследователя на оценку мышечной силы у животных в эксперименте: сравнение автоматизированного теста «перевернутая сетка» и его …

ПР Лебедев, ЕВ Кузубова… - Фармация и …, 2024 - pharmpharm.ru
Investigator’s influence on the muscle strength assessment in animals in experiment:
Comparison of automated “inverted gri Page 1 63 ОРИГИНАЛЬНАЯ СТАТЬЯ Том 12 …

[HTML][HTML] Limb-girdle muscular dystrophies

V Jain - medlink.com
The previous wastebasket term “limb girdle muscular dystrophy” has been transformed into
a multitude of specific, genetically defined disorders. In 2017, the European Neuromuscular …

[PDF][PDF] Department of Health Care Sciences, Physical Therapy Program, Wayne State University, Detroit MI, USA

M Begam, JA Roche - European Journal of Histochemistry, 2018 - pdfs.semanticscholar.org
We report that, labeling mouse muscle tissue, with mouse monoclonal antibodies specific to
slow or fast myosin heavy chain (sMyHC and fMyHC, respectively), can lead to artefactual …