The role of tandem repeat expansions in brain disorders

MA Panoyan, FR Wendt - Emerging Topics in Life Sciences, 2023 - portlandpress.com
The human genome contains numerous genetic polymorphisms contributing to different
health and disease outcomes. Tandem repeat (TR) loci are highly polymorphic yet under …

Analysis and benchmarking of small and large genomic variants across tandem repeats

AC English, E Dolzhenko, H Ziaei Jam… - Nature …, 2024 - nature.com
Tandem repeats (TRs) are highly polymorphic in the human genome, have thousands of
associated molecular traits and are linked to over 60 disease phenotypes. However, they …

Bioinformatics tools for the sequence complexity estimates

YL Orlov, NG Orlova - Biophysical Reviews, 2023 - Springer
We review current methods and bioinformatics tools for the text complexity estimates
(information and entropy measures). The search DNA regions with extreme statistical …

[HTML][HTML] WebSTR: a population-wide database of short tandem repeat variation in humans

OS Lundström, MA Verbiest, F Xia, HZ Jam… - Journal of molecular …, 2023 - Elsevier
Short tandem repeats (STRs) are consecutive repetitions of one to six nucleotide motifs.
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …

Recombination shapes the 2022 monkeypox (mpox) outbreak

TY Yeh, ZY Hsieh, MC Feehley, PJ Feehley… - Med, 2022 - cell.com
Monkeypox (Mpox) is a global health emergency. Yeh et al. analyze tandem repeats and
linkage disequilibrium in monkeypox virus (MPXV) sequences from the 2022 pandemic to …

STRPsearch: fast detection of structured tandem repeat proteins

S Mozaffari, PN Arrías, D Clementel, D Piovesan… - …, 2024 - academic.oup.com
Abstract Motivation Structured Tandem Repeats Proteins (STRPs) constitute a subclass of
tandem repeats characterized by repetitive structural motifs. These proteins exhibit distinct …

Expanding the repertoire of human tandem repeat RNA-binding proteins

A Ormazábal, MS Carletti, TE Saldaño… - Plos one, 2023 - journals.plos.org
Protein regions consisting of arrays of tandem repeats are known to bind other molecular
partners, including nucleic acid molecules. Although the interactions between repeat …

Short tandem repeat mutations regulate gene expression in colorectal cancer

MA Verbiest, O Lundström, F Xia, M Baudis… - Scientific Reports, 2024 - nature.com
Short tandem repeat (STR) mutations are prevalent in colorectal cancer (CRC), especially in
tumours with the microsatellite instability (MSI) phenotype. While STR length variations are …

A novel hypervariable variable number tandem repeat in the dopamine transporter gene (SLC6A3)

AT Apsley, ER Domico, MA Verbiest… - Life Science …, 2023 - life-science-alliance.org
The dopamine transporter gene, SLC6A3, has received substantial attention in genetic
association studies of various phenotypes. Although some variable number tandem repeats …

SOLeNNoID: A Deep Learning Pipeline For Solenoid Residue Detection in Protein Structures

GI Nikov, D Pretorius, JW Murray - bioRxiv, 2024 - biorxiv.org
Solenoid proteins are a subset of tandem repeat proteins, which are structurally distinct from
globular proteins. Solenoid proteins are defined by their modular, elongated structures …