Recent epidemiological and experimental work confirms that inorganic lead compounds are
associated with increased risks of tumorigenesis. In animals, these risks can be induced at …

Biomarkers of exposure, effect, and susceptibility are reviewed in relation to lead exposure.
Of the biomarkers of lead exposure, blood lead (Pb-B), mainly red cell lead, is a …

Exposure assessment is often considered the weakest link in risk assessment. It is important
for investigators to continue to utilize the full potential of biomarkers for chemicals whose …

Major strides have been taken in the regulation of lead intoxication in the general
population, but studies using genetic markers of susceptibility to environmental toxicants …

The ALAD gene (chromosome 9q34) codes for δ-aminolevulinic acid dehydratase
(ALAD)(EC 4.2. 1.24). ALAD catalyzes the second step of heme synthesis and is …

The battery industry is the largest consumer of lead, using an estimated 80% of the global
lead production. The industry is also rapidly expanding in emerging market countries. A …

Lead (Pb) is a widely used heavy metal with a broad industrial usage. Nevertheless, Pb is a
serious public health issue as it is one of the most widespread environmental and industrial …

The biosynthesis of porphyrins is one of the most conserved parthways known, about the
same sequence of reactions taking place in all species. By associating different metals …

A cross-sectional study was performed to evaluate the influence of polymorphisms in the
[delta]-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes on …

Metallic lead and several inorganic and organic lead compounds have been considered by
previous working groups convened by IARC (IARC, 1972, 1973, 1976, 1980, 1987). New …