Medical biology of cancer-associated fibroblasts in pancreatic cancer
Simple Summary Pancreatic cancer is a very deadly form of cancer with a low survival rate.
One important characteristic of pancreatic cancer is the presence of a dense tissue called …
One important characteristic of pancreatic cancer is the presence of a dense tissue called …
Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells
Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges for targeted
clinical interventions due to prevalent KRAS mutations, rendering PDAC resistant to RAF …
clinical interventions due to prevalent KRAS mutations, rendering PDAC resistant to RAF …
SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
BR Daley, HM Vieira, C Rao… - Proceedings of the …, 2023 - National Acad Sciences
KRAS is the most commonly mutated oncogene. Targeted therapies have been developed
against mediators of key downstream signaling pathways, predominantly components of the …
against mediators of key downstream signaling pathways, predominantly components of the …
The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/β-catenin to RTK/MAPK signaling
Wnts, cholesterol, and MAPK signaling are essential for development and adult
homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a …
homeostasis. Here, we report that fatty acid hydroxylase domain containing 2 (FAXDC2), a …
[HTML][HTML] Emerging horizons on molecular and circulating biomarkers in pancreatic adenocarcinoma
M Moretti, A Farina, A Angeloni… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of
pancreatic cancer and is expected to soon become the second leading cause of cancer …
pancreatic cancer and is expected to soon become the second leading cause of cancer …
AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
C Schneeweis, S Diersch, Z Hassan, L Krauß… - Cellular and Molecular …, 2023 - Springer
Targeting KRAS downstream signaling remains an important therapeutic approach in
pancreatic cancer. We used primary pancreatic ductal epithelial cells and mouse models …
pancreatic cancer. We used primary pancreatic ductal epithelial cells and mouse models …
Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling …
M Zou, Y Fu, Y Zhao, Y Sun, X Yin, X Peng - International …, 2022 - Elsevier
Mycoplasma gallisepticum (MG) is the main pathogen of chronic respiratory disease (CRD),
an infectious disease in chickens with high morbidity. Exosomal miRNAs are emerging as …
an infectious disease in chickens with high morbidity. Exosomal miRNAs are emerging as …
PDCD10 promotes the tumor-supporting functions of TGF-β in pancreatic cancer
Q Zhou, K Breitkopf-Heinlein, H Gaitantzi… - Clinical …, 2024 - portlandpress.com
The progression of pancreatic ductal adenocarcinoma (PDAC) is significantly affected by
transforming growth factor (TGF)-β but targeting TGF-β can also compromize physiological …
transforming growth factor (TGF)-β but targeting TGF-β can also compromize physiological …
Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors
Serine/threonine kinase AKT isoforms play a well-established role in cell metabolism and
growth. Most pancreatic adenocarcinomas (PDACs) harbor activation mutations of KRAS …
growth. Most pancreatic adenocarcinomas (PDACs) harbor activation mutations of KRAS …
Selumetinib—A Comprehensive Review of the New FDA-Approved Drug for Neurofibromatosis
Selumetinib is a drug that inhibits the mitogen‑activated protein kinase (MAPK) pathway.
This pathway has a role in different cellular functions, eg, growth regulation, cell division …
This pathway has a role in different cellular functions, eg, growth regulation, cell division …