To effectively build on the recent successes of immune checkpoint blockade, adoptive T cell
therapy and cancer vaccines, it is critical to rationally design combination strategies that will …

Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no
damage to normal cells in the process. Because of their specific features, such as, the ability …

Abstract Background Brain metastases (BrM) incidence is 25% to 50% in women with
advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer …

The strategy of using mesenchymal stem cells (MSCs) as a living carrier for active delivery of
therapeutic agents targeting tumor sites has been attempted in a wide range of studies to …

The recent Food and Drug Administration approval of immunogenic oncolytic virus (OV) has
opened a new era in the treatment of advanced melanoma; however, approximately 50% of …

Progress in genetic engineering led to the emergence of some viruses as potent anticancer
therapeutics. These oncolytic viruses combine self-amplification with dual antitumor action …

A significant number of clinical trials have been undertaken to explore the use of
mesenchymal stem cells (MSCs) for the treatment of several diseases such as Crohn's …

With the increased worldwide burden of cancer, including aggressive and resistant cancers,
oncolytic virotherapy has emerged as a viable therapeutic option. Oncolytic herpes simplex …

Oncolytic viruses (OVs) are an emerging class of therapeutics which combine multiple
mechanisms of action, including direct cancer cell-killing, immunotherapy and gene therapy …