Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people
worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a …

Introduction Despite the availability of around 30 antiseizure medications, 1/3 of patients
with epilepsy fail to become seizure-free upon pharmacological treatment. Available …

The lack of disease-modifying therapeutic strategies against epileptic seizures has caused a
surge in preclinical research focused on exploring and developing novel therapeutic …

SoxB1 genes play fundamental roles in neurodevelopmental processes and maintaining
stem cell multipotency, but little is known about their function in regeneration. We addressed …

Ethnopharmacological relevance Cymbopogon citratus (DC.) Stapf (C. citratus) is consumed
as an infusion in folk medicine due to its pharmacological properties and action in the …

Epilepsy, a clinical diagnosis characterised by paroxysmal episodes known as seizures,
affects 1% of people worldwide. Safe and patient‐specific treatment is vital and can be …

A common way to investigate epilepsy and the effect of antiepileptic pharmaceuticals is to
analyze the movement patterns of zebrafish larvae treated with different convulsants like …

Epilepsy is one of the most prevalent neurological disorders, affecting more than 45 million
people worldwide. Recent advances in genetic techniques, such as next-generation …

Background Locomotor assays in zebrafish have emerged as a screening test in early drug
discovery for antiseizure compounds. However, parameters differ considerably between …

Here we report on a small library based on a 4-aminobenzonitile-s-triazine moiety. We used
a straightforward orthogonal synthetic pathway to prepare di-and tri-substituted s-triazine …