Apoptosis and the clearance of apoptotic cells are essential processes in animal
development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat …

Phosphatidylserine (PtdSer) is a phospholipid that is abundant in eukaryotic plasma
membranes. An ATP-dependent enzyme called flippase normally keeps PtdSer inside the …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in
eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma …

It is well known that lipids are heterogeneously distributed throughout the cell. Most lipid
species are synthesized in the endoplasmic reticulum (ER) and then distributed to different …

To maintain organismal homeostasis, phagocytes engulf dead cells, which are recognized
as dead by virtue of a characteristic" eat me" signal exposed on their surface. The dead cells …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

Asymmetrical distribution of phospholipids between the inner and outer plasma membrane
leaflets is disrupted in various biological processes. We recently identified TMEM16F, an …