Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Meticillin-resistant Staphylococcus aureus (MRSA) remains one of the principal multiply
resistant bacterial pathogens causing serious healthcare-associated and community-onset …

Background Clinical practice guidelines or recommendations often require timely and
regular updating as new evidence emerges, because this can alter the risk-benefit trade-off …

Background Vancomycin area under the concentration‐time curve (AUC) has been linked to
efficacy and safety. An accurate method of calculating the AUC is needed. Methods …

Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

Objectives Vancomycin is a vital treatment option for patients suffering from critical
infections, and therapeutic drug monitoring is recommended. Bayesian forecasting is …

Vancomycin is a fundamental antibiotic in the management of severe Gram‐positive
infections. Inappropriate vancomycin dosing is associated with therapeutic failure, bacterial …

Many important drugs exhibit substantial variability in pharmacokinetics and
pharmacodynamics leading to a loss of the desired clinical outcomes or significant adverse …

Vancomycin, a glycopeptide antibiotic, is the first line agent in the treatment of penicillinase-
producing strains of Staphylococcus aureus and is increasingly used in Australian hospitals …

BACKGROUND: Conflicting evidence regarding the association of vancomycin serum
concentrations with efficacy and toxicity has resulted in controversy regarding optimal target …