Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Cancer is a frightful disease and represents one of the biggest health-care issues for the
human race and demands a proactive strategy for cure. Plants are reservoirs for novel …

The chemical investigation of marine mollusks has led to the isolation of a wide variety of
bioactive metabolites, which evolved in marine organisms as favorable adaptations to …

Abstract Ponatinib (Iclusig, ARIAD Pharmaceuticals-Incyte Co.) is a third-generation
structure-guided tyrosine kinase inhibitor that is approved for treatment of Philadelphia …

Through years of evolutionary selection pressures, organisms have developed potent toxins
that coincidentally have marked antineoplastic activity. These natural products have been …

Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60
years. Significant activity against leukemia in mice was demonstrated for extracts of …

Cephalotaxus is the only genus of Cephalotaxaceae family, and its natural resources are
declining due to habitat fragmentation, excessive exploitation and destruction. In many …

BACKGROUND Omacetaxine, a protein synthesis inhibitor, is indicated in the United States
for the treatment of patients with chronic‐phase (CP) or accelerated‐phase (AP) chronic …

A facile Stevens rearrangement of the Weinreb amide and the subsequent key steps
mediated by the carbonyl of the Weinreb amide led to the construction of azaspirocyclic …

Imatinib revolutionized the therapy of chronic myeloid leukemia (CML), but the resistance to
it became an emerging problem. We reported previously that CML cells expressing the …