Advances in local therapy for glioblastoma—taking the fight to the tumour
TS van Solinge, L Nieland, EA Chiocca… - Nature Reviews …, 2022 - nature.com
Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …
Tumor cell invasion in glioblastoma
A Vollmann-Zwerenz, V Leidgens, G Feliciello… - International journal of …, 2020 - mdpi.com
Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16
months. Recent research has revealed novel insights into the outstanding heterogeneity of …
months. Recent research has revealed novel insights into the outstanding heterogeneity of …
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma
H Liu, Q Zhao, L Tan, X Wu, R Huang, Y Zuo, L Chen… - Cancer cell, 2023 - cell.com
Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To
explore the underlying immune regulators, we examine the microenvironment in glioma and …
explore the underlying immune regulators, we examine the microenvironment in glioma and …
A review of newly diagnosed glioblastoma
B Oronsky, TR Reid, A Oronsky, N Sandhu… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …
Multispecific targeting of glioblastoma with tumor microenvironment-responsive multifunctional engineered NK cells
Tumor antigen heterogeneity, a severely immunosuppressive tumor microenvironment
(TME) and lymphopenia resulting in inadequate immune intratumoral trafficking, have …
(TME) and lymphopenia resulting in inadequate immune intratumoral trafficking, have …
Sex-specific differences in glioblastoma
Sex differences have been well identified in many brain tumors. Even though glioblastoma
(GBM) is the most common primary malignant brain tumor in adults and has the worst …
(GBM) is the most common primary malignant brain tumor in adults and has the worst …
Myeloid cells in glioblastoma microenvironment
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …