Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

The complex etiological factors associated with metabolic dysfunction-associated fatty liver
disease (MAFLD), including perturbed iron homeostasis, and the unclear nature by which …

Regulation of cell mortality for disease treatment has been the focus of research. Ferroptosis
is an iron-dependent regulated cell death whose mechanism has been extensively studied …

Background & Aims Pioglitazone (Pio) is efficacious in NASH, but its utility is limited by
PPARγ-driven side effects. Pio is a mixture of two enantiomers (R, S). PXL065, deuterium …

Ferroptosis is a novel type of programmed cell death that differs from apoptosis in that it
involves iron-dependent peroxidation of membrane phospholipids. Its role in a variety of …

Ferroptosis is a programmed cell death pathway that is recently linked to Parkinson's
disease (PD), where the key genes and molecules involved are still yet to be defined. Acyl …

Simple Summary ACSL4 is an enzyme involved in the intracellular conversion of long-chain
fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various …

NASH is a highly prevalent metabolic syndrome that has no specific approved agents up to
now. BBBP, which mainly contains bile acids, possess various pharmacological properties …

Long-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4) is an enzyme that esterifies CoA
into specific polyunsaturated fatty acids, such as arachidonic acid and adrenic acid. Based …