Purpose: The purpose of this article is to review the evidence for the hypothesis that the core
mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic …

Dry eye disease (DED) is a distressing ocular condition. Due to its multifactorial nature,
clinical and biological signs of DED can be inconsistent and sometimes discordant with …

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively
reported for its efficacy in controlling or treatment of several inflammatory diseases. There is …

Background—It is recognized that inflammation is an underlying cause of dry eye disease
(DED), with cytokine release involved. We systematically reviewed literature with meta …

Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on
vision and quality of life. It is now well recognized that the pathophysiology of chronic DED …

Dry eye disease (DED) is a multifactorial ocular surface disorder arising from numerous
interrelated underlying pathologies that trigger a self-perpetuating cycle of instability …

Purpose To determine if controlled environmental conditions can induce acute
exacerbations of signs and symptoms in dry eye and asymptomatic subjects. Design …

Nuclear factor of activated T cells 5 (NFAT5) is the most recently described member of the
Rel family of transcription factors, including NF-κB and NFAT1-4, which play central roles in …

Over 100 million individuals are affected by irreversible visual impairments and blindness
worldwide, while ocular diseases remain a challenging problem despite significant …

Purpose: Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE);
however, the mechanisms that underlie this symptom remain uncertain. The aim of this study …