The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …

Cardiac involvement has a profound effect on the prognosis of patients with systemic
amyloidosis. Therapeutic methods for suppressing the production of causative proteins have …

Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of
misfolded proteins called amyloid and is often an early manifestation of systemic …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid
plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body …

Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation
in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv,“v” for variant) …

Protein misfolding and aggregation are associated with a number of human degenerative
diseases. In spite of the enormous research efforts to develop effective strategies aimed at …

Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause
of heart failure due to misfolded wild-type transthyretin (TTRwt) myocardial deposition. The …

Aggregation of human wild-type transthyretin (hTTR), a homo-tetrameric plasma protein,
leads to acquired senile systemic amyloidosis (SSA), recently recognised as a major cause …

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed disease
associated with high mortality rates and the patient journey is characterized by increased …