Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a
ubiquitous mechanism underlying the organization of biomolecules in space and time. Here …

In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …

This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

Liquid–liquid phase separation has drawn attention as many neurodegeneration or cancer-
associated proteins are able to form liquid membraneless compartments (condensates) by …

The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …

Hypoxia inhibits the tricarboxylic acid (TCA) cycle and leaves glycolysis as the primary
metabolic pathway responsible for converting glucose into usable energy. However, the …