Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

How cancer cells acquire the competence to colonize distant organs remains a central
question in cancer biology. Tumors can release large numbers of cancer cells into the …

Metastasis to distant organs is an ominous feature of most malignant tumours but the natural
history of this process varies in different cancers. The cellular origin, intrinsic properties of …

Metastasis occurs when genetically unstable cancer cells adapt to a tissue
microenvironment that is distant from the primary tumor. This process involves both the …

Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

Patients with cancer can develop recurrent metastatic disease with latency periods that
range from years even to decades. This pause can be explained by cancer dormancy, a …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare
tumour cells that overcame stringent physiological barriers as they separated from their …

Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …

Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …