[HTML][HTML] The molecular basis of antimalarial drug resistance in Plasmodium vivax

LE Buyon, B Elsworth, MT Duraisingh - International Journal for …, 2021 - Elsevier
Plasmodium vivax is the most geographically widespread cause of human malaria and is
responsible for the majority of cases outside of the African continent. While great progress …

[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Genomic analysis of local variation and recent evolution in Plasmodium vivax

RD Pearson, R Amato, S Auburn, O Miotto… - Nature …, 2016 - nature.com
The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …

SeekDeep: single-base resolution de novo clustering for amplicon deep sequencing

NJ Hathaway, CM Parobek, JJ Juliano… - Nucleic acids …, 2018 - academic.oup.com
PCR amplicon deep sequencing continues to transform the investigation of genetic diversity
in viral, bacterial, and eukaryotic populations. In eukaryotic populations such as Plasmodium …

Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections

A Lerch, C Koepfli, NE Hofmann, C Messerli, S Wilcox… - BMC genomics, 2017 - Springer
Background Amplicon deep sequencing permits sensitive detection of minority clones and
improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections …

[HTML][HTML] Recent advances in understanding apicomplexan parasites

F Seeber, S Steinfelder - F1000Research, 2016 - ncbi.nlm.nih.gov
Intracellular single-celled parasites belonging to the large phylum Apicomplexa are amongst
the most prevalent and morbidity-causing pathogens worldwide. In this review, we highlight …

Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia–Pacific region

R Noviyanti, O Miotto, A Barry, J Marfurt, S Siegel… - 2020 - Springer
Abstract The Asia–Pacific region faces formidable challenges in achieving malaria
elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites …

Transmission dynamics of co-endemic Plasmodium vivax and P. falciparum in Ethiopia and prevalence of antimalarial resistant genotypes

E Lo, E Hemming-Schroeder, D Yewhalaw… - PLoS neglected …, 2017 - journals.plos.org
Ethiopia is one of the few African countries where Plasmodium vivax is co-endemic with P.
falciparum. Malaria transmission is seasonal and transmission intensity varies mainly by …

Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics

C Bourgard, L Albrecht, ACAV Kayano… - Frontiers in cellular …, 2018 - frontiersin.org
During the last decade, the vast omics field has revolutionized biological research,
especially the genomics, transcriptomics and proteomics branches, as technological tools …

Amplicon deep sequencing improves Plasmodium falciparum genotyping in clinical trials of antimalarial drugs

M Gruenberg, A Lerch, HP Beck, I Felger - Scientific Reports, 2019 - nature.com
Clinical trials monitoring malaria drug resistance require genotyping of recurrent
Plasmodium falciparum parasites to distinguish between treatment failure and new infection …