Phospholipase A2 (PLA2) enzymes are considered the primary source of arachidonic acid
for cyclooxygenase (COX)–mediated biosynthesis of prostaglandins. Here, we show that a …

The brain and the peripheral (hormonal) angiotensin II systems are stimulated during stress.
Activation of brain angiotensin II AT1 receptors is required for the stress-induced hormone …

Background and Purpose Since monoacylglycerol lipase (MAGL) has been firmly
established as the predominant catabolic enzyme of the endocannabinoid 2 …

We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)–
induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous …

Stress reduces gastric blood flow and produces acute gastric mucosal lesions. We studied
the role of angiotensin II in gastric blood flow and gastric ulceration during stress …

Objective To examine whether activated protein C (APC) reduces spinal cord injury in rats
by inhibiting neutrophil activation after the transient ischemia. Summary Background Data …

Stress ulceration is a common complication in critically ill patients and can result in
significant upper gastrointestinal bleeding associated with a high morbidity and mortality. At …

Arginine-rich peptide motifs (ARMs) capable of binding unique RNA structures play critical
roles in transcription, translation, RNA trafficking, and RNA packaging. Bacteriophage ARMs …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics, but can
cause gastric and esophageal hemorrhages, erosion, and ulceration. The endogenous …

Background and Purpose Inhibition of diacylglycerol lipase (DGL) β prevents LPS‐induced
pro‐inflammatory responses in mouse peritoneal macrophages. Thus, the present study …