The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …

Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Objective Our previous studies found that disturbances in gut microbiota might have a
causative role in the onset of major depressive disorder (MDD). The aim of this study was to …

Bile acids are signalling hormones involved in the regulation of several metabolic pathways.
The ability of bile acids to bind and signal through their receptors is modulated by the gut …

Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

Background The majority of the critically ill patients may have critical illness-related
corticosteroid insufficiency (CIRCI). The therapeutic effect of dexamethasone may be related …

Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Critical illnesses are characterized by increased systemic cortisol availability, which is a vital
part of the stress response. Relative adrenal failure (later termed critical-illness-related …

Bile acids are synthesized from cholesterol and are known to be involved with the
emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role …