Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery

B Kim, JH Park, MJ Sailor - Advanced materials, 2019 - Wiley Online Library
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Core–shell nanostructures: perspectives towards drug delivery applications

R Kumar, K Mondal, PK Panda, A Kaushik… - Journal of Materials …, 2020 - pubs.rsc.org
Nanosystems have shown encouraging outcomes and substantial progress in the areas of
drug delivery and biomedical applications. However, the controlled and targeted delivery of …

Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy

S Hussain, J Joo, J Kang, B Kim, GB Braun… - Nature biomedical …, 2018 - nature.com
Bacterial resistance to antibiotics has made it necessary to resort to using antibacterial drugs
that have considerable toxicities. Here, we show that conjugation of vancomycin-loaded …

Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

W Li, Z Liu, F Fontana, Y Ding, D Liu… - Advanced …, 2018 - Wiley Online Library
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …

Graphene: a versatile platform for nanotheranostics and tissue engineering

RG Bai, N Ninan, K Muthoosamy… - Progress in Materials …, 2018 - Elsevier
The sustained extensive research on graphene and its derivatives in the last decade
portrayed its significance in the field of material science and carved its own niche in …

Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus

B Kim, HB Pang, J Kang, JH Park, E Ruoslahti… - Nature …, 2018 - nature.com
The incidence of adverse effects and pathogen resistance encountered with small molecule
antibiotics is increasing. As such, there is mounting focus on immunogene therapy to …

Design and validation of liposomal ApoE2 gene delivery system to evade blood–brain barrier for effective treatment of Alzheimer's disease

S Arora, B Layek, J Singh - Molecular pharmaceutics, 2020 - ACS Publications
Targeting gene-based therapeutics to the brain is a strategy actively sought to treat
Alzheimer's disease (AD). Recent findings discovered the role of apolipoprotein E (ApoE) …

Graphene oxide thin films with drug delivery function

AML Oliveira, M Machado, GA Silva, DB Bitoque… - Nanomaterials, 2022 - mdpi.com
Graphene oxide has been used in different fields of nanomedicine as a manager of drug
delivery due to its inherent physical and chemical properties that allow its use in thin films …

[HTML][HTML] Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke

S Parvez, M Kaushik, M Ali, MM Alam, J Ali… - Theranostics, 2022 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is one of the leading causes of death and disability resulting in
inevitable burden globally. Ischemic injury initiates cascade of pathological events …

Recent advances in the application of two-dimensional nanomaterials for neural tissue engineering and regeneration

A Halim, KY Qu, XF Zhang… - ACS Biomaterials Science …, 2021 - ACS Publications
The complexity of the nervous system structure and function, and its slow regeneration rate,
makes it more difficult to treat compared to other tissues in the human body when an injury …